Thin Films for the physical and life sciences in high-technology applications.

Shelf life

We do not observe a specific degradation with time of the BioNano gold substrates if they are stored and handled properly. However, we recommend the use of the substrate within a year after reception.

 

BioNano gold main page

Tweezers

 

tweezers for glass slides

 

 

Phasis provides special tweezers made by Ideal-Tek SA, a Swiss company. These tweezers are ideal for handling the Bionano gold glass slides. They have indeed large tips allowing holding your sample in a secure way. 

Phasis also provide tweezers for the gold on mica products.

 

Catalog # Product  Description Picture  
50030010 tweezers Tweezers for the gold on mica products tweezers for gold on mica
 
50030011 tweezers Tweezers for the BioNano gold products tweezers for glass slides
 

 

BioNano gold main page

Au111 on mica main page

Surface Plasmon Resonance (SPR) studies

BioNano gold thin films are widely used in surface plasmon (SPR) resonance studies. SPR technology has become a leading technology in the field of real-time observation of biomolecular interactions.

 

Typical SPR measurement:

In a standard configuration, the BioNano gold glass slide is placed in contact with a prism using an index matching fluid. Polarized light is shined from the backside of the substrate. The reflected intensity is measured as a function of the angle, or at a fixed angle and as a function of time. The following picture is a drawing of the reflected intensity as a function of the angle.

SPR drawing

 

Surface plasmon resonance is observed as a sharp dip in the reflected intensity. The angle at which the resonance is observed is dependent on the mass of material at the surface for a given optical setup. The SPR angle shifts when molecules bind to the surface and change the mass of the layer. Surface plasmons are surface electromagnetic waves that propagate along a metal - dielectric interface. These waves are sensitive to changes at this interface induced by the adsorption of molecules to the metal surface.

For the monitoring of a molecular interactions in real-time, the SPR signal is measured at a fixed angle close to the minimum of the dip and changes in the reflected intensity are observed as a function of time.


Examples of SPR applications:

  • Surface plasmon resonance (SPR) technology is used in the drug discovery process by the pharmaceutical industry. In the case of a monitoring of a molecular interaction, a ligand, one binding partner is immobilized on the gold surface and an analyte, the other binding partner is injected over the surface to measure the binding interaction. To learn more, see R. L. Rich, and D. G. Myszka, Today Technologies, vol 1 n°3 (2004). For a review on optical biosensors in drug discovery see: M. A. Cooper, Nature Reviews 1 (2002), 515.
  • Surface plasmon resonance (SPR) biosensors are becoming increasingly important in the food industry for application in safety and quality control. This technology is for instance used to test veterinary drug residues in foodstuffs and has been used to detect genetically modified organisms (GMOs). To learn more, see Journal of AOAC International, vol 89, issue 3 (2006). Atypon-link.com.
  • SPR technology can also be used to monitor the thickness of adsorbed self-assembled films on the metal surface. For a review on surface plasmon resonance sensors, see J. Homola et al, Sensors and Actuators B 54 (1999) 3-15.


Digital Holographic Microscope (DHM) studies

BioNano gold thin films are used as substrates for various organic or inorganic species studied with a digital holographic microscope. For more information about the DHM, see the website of Lyncée Tec SA.

Teaching and Presentations

BioNano gold thin films are used for scanning probe microscopy (SPM) studies for educational purposes. The substrates can be advantageously used to study the growth of metals on glass, and to let students learn about atomic force microscopy.

 

BioNano gold main page

Growth

BioNano gold thin films are grown in controlled high vacuum deposition systems using a magnetron sputtering technique. Details on the deposition technique can be found here. Prior to deposition, the glass microscope slides are cleaned with a plasma procedure. The gold source targets are made of pure gold 99.99% and pure titanium 99.995%. The typical gold thickness we provide is 10, 50 and 100 nm. We can grow films with different thickness upon request. Do not hesitate to contact us if you have a request for a special gold geometry.

Thin Film Quality

The surface quality of the thin films is tested using atomic force microscopy (AFM). We measure a typical surface roughness lower than 2 nm over 10 x 10 mm2 During the production process, the surface quality of our films is regularly controlled.

 

BioNano gold main page

BioNano GoldBioNano substrates are produced on different glass slides with or without a titanium adhesion layer. The films are grown in controlled high vacuum deposition systems. The coatings present very smooth surfaces with very low root mean square roughness.

Phasis also provides gold on mica

Advantages of our Products

  • Different glasses are available to meet your requirements.
  • BioNano Gold
  • Different glass sizes are available to fit your instrumentation.
  • The glass is cleaned prior deposition.
  • Precise control over the gold thickness.
  • We offer a titanium adhesion layer.
  • Suited for Surface Plasmon Resonance (SPR) experiments.
  • The gold source target is made of pure gold 99.99% and substrates are grown in a clean and dedicated environment.

More about

Products

Glass slides dimensions: 75 mm x 25 mm x 1.1 mm, Glass: Borosilicate.

Glass properties

Catalog # Product  Glass substrate dimension
Au deposited region
Gold Thickness
over Titanium adhesion layer
Unit
 
30020010 Bionano gold coated borosilicate glass slides 75 mm x 25 mm x 1.1 mm 65 mm x 25 mm 10 nm Pack of 5
30020011 Bionano gold coated borosilicate
 glass slides
75 mm x 25 mm x 1.1 mm 65 mm x 25 mm 50 nm Pack of 5
30020012 Bionano gold coated borosilicate
 glass slides
75 mm x 25 mm x 1.1 mm 65 mm x 25 mm 100 nm Pack of 5

Glass slides dimensions: 75 mm x 25 mm x 1.1 mm, Glass: SF10.

Glass properties

Catalog # Product  Glass substrate dimension
Au deposited region
Gold Thickness
over Titanium adhesion layer
Unit
 
30030010 Bionano gold coated SF10 glass slides 75 mm x 25 mm x 1.1 mm 65 mm x 25 mm 10 nm Pack of 1
30030011 Bionano gold coated SF10
 glass slides
75 mm x 25 mm x 1.1 mm 65 mm x 25 mm 50 nm Pack of 1
30030012 Bionano gold coated SF10
 glass slides
75 mm x 25 mm x 1.1 mm 65 mm x 25 mm 100 nm Pack of1


Glass dimensions: 76 mm x 25 mm x 1 mm, Glass: Quartz.

Glass properties

Catalog # Product  Glass substrate dimension
Au deposited region
Gold Thickness
over Titanium adhesion layer
Unit
 
30040010 Bionano gold coated quartz glass slides 76 mm x 25 mm x 1 mm 66 mm x 25 mm 10 nm Pack of 5
30040011 Bionano gold coated quartz glass slides 76 mm x 25 mm x 1 mm 66 mm x 25 mm 50 nm Pack of 5
30040012 Bionano gold coated quartz glass slides 76 mm x 25 mm x 1 mm 66 mm x 25 mm 100 nm Pack of 5

Glass dimensions: 25 mm x 25 mm x 1.1 mm, Glass: Borosilicate.

Glass properties

Catalog # Product  Glass substrate dimension
Au deposited region
Gold Thickness
over Titanium adhesion layer
Unit
 
30020020 Bionano gold coated borosilicate glass slides 25 mm x 25 mm x 1.1 mm 25 mm x 22 mm 10 nm Pack of 1
30020021 Bionano gold coated borosilicate
 glass slides
25 mm x 25 mm x 1.1 mm 25 mm x 22 mm 50 nm Pack of 1
30020022 Bionano gold coated borosilicate
 glass slides
25 mm x 25 mm x 1.1 mm 25 mm x 22 mm 100 nm Pack of 1

Glass dimensions: 25 mm x 25 mm x 1 mm, Glass: Quartz.

Glass properties

Catalog # Product  Glass substrate dimension
Au deposited region
Gold Thickness
over Titanium adhesion layer
Unit
 
30040020 Bionano gold coated quartz glass slides 25 mm x 25 mm x 1 mm 25 mm x 22 mm 10 nm Pack of 1
30040021 Bionano gold coated quartz glass slides 25 mm x 25 mm x 1 mm 25 mm x 22 mm 50 nm Pack of 1
30040022 Bionano gold coated quartz glass slides 25 mm x 25 mm x 1 mm 25 mm x 22 mm 100 nm Pack of 1

Coverslips dimensions: 22 mm x 22 mm x 0.15 mm, Glass: Borosilicate.

Glass properties

Catalog # Product  Glass substrate dimension Au deposited region Gold Thickness over Titanium adhesion layer Unit  
40020010 Bionano gold coated borosilicate coverslips 22 mm x 22 mm x 0.15 mm 22 mm x 19.5 mm 10 nm Pack of 5
40020011 Bionano gold coated borosilicate coverslips 22 mm x 22 mm x 0.15 mm 22 mm x 19.5 mm 50 nm Pack of 5
40020012 Bionano gold coated borosilicate coverslips 22 mm x 22 mm x 0.15 mm 22 mm x 19.5mm 100 nm Pack of 5

Coverslips dimensions: 15 mm x 15 mm x 0.15 mm, Glass: Borosilicate.

Glass properties

Catalog # Product  Glass substrate dimension Au deposited region Gold Thickness over Titanium adhesion layer Unit  
40030010 Bionano gold coated borosilicate coverslips 15 mm x 15 mm x 0.15 mm 15 mm x 13 mm 10 nm Pack of 5
40030011 Bionano gold coated borosilicate coverslips 15 mm x 15 mm x 0.15 mm 15 mm x 13 mm 50 nm Pack of 5
40030012 Bionano gold coated borosilicate coverslips 15 mm x 15 mm x 0.15 mm 15 mm x 13 mm 100 nm Pack of 5

The typical gold thickness we provide is 10, 50 and 100 nm. We can grow films with different thickness upon request.

We can coat the glass without a titanium adhesion layer.

Do not hesitate to contact us if you have a request for a special gold geometry.